Preparation of Sol-Gel Molecularly Imprinted Polymer Based on Tetraethoxysilane for Recognize Sulfonamides
نویسنده
چکیده
Synthesis of an inorganic molecularly imprinted polymer (MIP) composed of tetraethoxysilane (TEOS) for recognize sulfonamides using a sol-gel process have been developed. The template, sulfamethazine (SMZ), was dissolved in acid aqueous solution and added into TEOS to formed the precursor solution and adjusted the pH by various ammonium hydroxide (NH4OH) and reacted for 3 days. After the reaction, MIP was obtained by calcination with various temperature processes. The preparation conditions, the various adsorption time intervals, the amount of NH4OH and the calcination temperature process were discussed. Adsorption and selectivity in different pH solutions were determined by competition experiments between the MIP template (SMZ) and the analogue (sulfamethoxazole, SMO) using High-Performance Liquid Chromatography (HPLC). The results showed that the adsorption and selectivity of the competition solution with pH=7.4 were higher than those with pH=4.6. In addition, the adsorption of SMZ decreased but the selectivity increased while increasing the calcinations time. Besides, the selectivity of the MIP (51.3) was approximately eight times greater than the non-imprinted polymer (6.55) under the optimum preparation conditions.
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